Further studies on functionally connected hub genes (such as UBC, ITGA4, HSP90AB1, VCAM1, VCP), other potential seed genes (e.g., CDKN1A, CDKN2A, MMP9, IGF1, MKI67), DEMs and their multidimensional networking with regulatory transcription factors are needed for better understanding of their oncogenic/ anti tumor properties and to explore their synergistic prognostic value. This evidence concerns the gene MMP9 and neoplasm.