On the basis of our data, we suggest that expression of PTENP1-AS is induced by the TF C/EBPB in BRAFi resistant melanoma cell lines, which results in transcriptional suppression of PTEN through the recruitment of EZH2 with subsequent formation of H3K27me3 (Fig. 3b,c) and DNA methylation of the PTEN promoter (Fig. 3a). This evidence concerns the gene EZH2 and melanoma.