Yang et al. showed that miR-146a derived from BC exosomes enhanced the transformation of normal fibroblasts (NFs) into cancer-associated fibroblasts (CAFs) via miR-146a/thioredoxin-interacting protein (TXNIP) axis to promote the Wnt pathway in TME, contributing to the accelerated invasion and metastasis of BC cells46. The gene discussed is TXNIP; the disease is cancer.