A number of these HBO1-regulated genes play oncogenic roles in HCC, including C‐C chemokine receptor type 2 (CCR2)35,36, myosin light chain kinase (MYLK)37, VEGFR238,39, Homeobox A10 (HOXA10)40,41, pre-leukemia transcription factor 3 (PBX3)42,43 and frizzled-related protein (FRZB)44. Here, CCR2 is linked to hepatocellular carcinoma.