In KO-HBO1 HCC-1 cells, HBO1-regulated mRNAs, including MYLK, VEGFR2, PBX3, CCR2, HOXA10, and FRZB21,34, were dramatically downregulated (Fig. S1B), β-catenin protein levels were decreased as well (Fig. 4B). This evidence concerns the gene CCR2 and hepatocellular carcinoma.