Ibrahim et al reported that PI3K inhibition resulted in the compensatory activation of MAPK/ERK pathway, thus phosphorylated and activated ETS (E26 Transformation-specific Sequence) transcription factors to reduce BRCA1/2 transcription through repressing the BRCA1/2 promoter, eventually induced HR repair deficiency in triple-negative breast cancer cells21. The gene discussed is PIK3CB; the disease is triple-negative breast carcinoma.