Intriguingly, our integrated WGS and tNGS data analysis found CCR6 (15%), DAPK1 (15%), TNFRSF21 (13%), and CCR7 (11%) mutations as reoccurring and specific features of EBV + DLBCL (NOS), when compared with other subtypes of DLBCL. This evidence concerns the gene CCR6 and diffuse large B-cell lymphoma.