Next, we compared binding profiles of CEBPA enhancers between the CEBPA-expressing hepatocellular carcinoma (HCC) cell line HepG2 and non-CEBPA-expressing cell line HeLa by aligning ChIP-seq tracks (ENCODE) of H3K27ac, Pol II, Pol II Ser2, p300, and CEBPB. This evidence concerns the gene EP300 and hepatocellular carcinoma.