Currently, other main anti-CD33 T-cell engaging bsAbs have entered clinical development and are in phase 1 clinical study in patients with R/R AML, including JNJ-67571244 [54], affinity-tailored adaptors for T-cells (ATAC) GEM333 [55], and TandAb AMV 564 [56]. This evidence concerns the gene CD33 and acute myeloid leukemia.