Collectively, it was drawn from this research that HCC-exo delivered DLX6-AS1 to macrophages to stimulate M2 macrophage polarization, thus to irritate the invasion, migration and EMT of HCC cells in vitro and lung metastasis in vivo, which was related to the regulation of miR-15a-5p/CXCL17 axis. The gene discussed is DLX6; the disease is hepatocellular carcinoma.