ADAMTS1 and hyperplastic polyp: To date, numerous chromosomal loci implicated in MP pathogenesis have been reported, and also a host of genes that predispose MP, such as EPB41, MATN1, COL2A1, MYO1H, TGFB3, LTBP2, ADAMTS1, DUSP6, FGFR2, and FGF23. Most of these studies were based on family linkage studies.