To date, numerous chromosomal loci implicated in MP pathogenesis have been reported, and also a host of genes that predispose MP, such as EPB41, MATN1, COL2A1, MYO1H, TGFB3, LTBP2, ADAMTS1, DUSP6, FGFR2, and FGF23. Most of these studies were based on family linkage studies. This evidence concerns the gene TGFB3 and hyperplastic polyp.