ABCA12 and lamellar ichthyosis: The severity of mutations of the ABCA12 gene is related to the clinical phenotype; other less serious pathologies such as lamellar ichthyosis and congenital ichthyosiform erythroderma are associated with partial defects in the function of the ABCA12 gene, in contrast, mutations that produce complete loss of this gene function generate HI [3, 6, 9].