VANGL1 and colorectal carcinoma: Thus, we speculate that miRNAs modulated by the KITENIN complex are responsible for the blunted cytotoxic response to 5-FU or oxaliplatin in CRC cells expressing higher levels of KITENIN, and that recovery or upregulation of miRNAs after DKC1125 treatment are responsible for restoring chemosensitivity to 5-FU or oxaliplatin.