Therefore, binding of KSRP with Dvl under KITENIN overexpression may modulate CRC cell invasiveness through activation of canonical WNT signaling, and blocking the KITENIN-KSRP-Dvl axis by DKC1125 may be due to abrogation of KSRP-Dvl2 binding. This evidence concerns the gene VANGL1 and colorectal carcinoma.