Invasion by HCT116 cells, the CRC cells with the highest endogenous KITENIN levels [12], was inhibited by treatment with 0.5 μM DKC1125-linker-Ac (0.5 μM, Fig. 1b) to a similar extent as with free DKC115, i.e., DKC1125 and linker-attached DKC1125 had the same activity. Here, VANGL1 is linked to colorectal carcinoma.