VANGL1 and colorectal carcinoma: Because DKC1125 increased the suppressive effect of 5-FU on cell survival and motility in KITENIN-overexpressing CRC cells (Figs. 7a and e), we next investigated the in vivo effect of DKC1125 on distant metastasis of CRC in a mouse model of hepatic metastases using a combinatorial strategy, alone or combination with 5-FU.