Taken together, these observations imply that miR-124-3p modulates the KITENIN-KSRP axis, in which its own expression is also regulated, and the increase in mature miR-124-3p by DKC1125 negatively regulates the KITENIN complex and thereby inhibits the invasiveness of CRC cells expressing higher levels of KITENIN (KITENIN-GOF). The gene discussed is VANGL1; the disease is colorectal carcinoma.