It is noteworthy, however, that both the morphological and behavioral changes observed in LCN-2 null mice are in line with those observed in animals after chronic stress exposure or prolonged administration of exogenous glucocorticoids [36], which raises the question whether or not LCN2 is also involved in the regulation of the stress response, a feature that is known to be disrupted in a number of psychiatric diseases, for instance, OCD. Here, LCN2 is linked to psychiatric disorder.