To sum up, lncRNA TUG1 promoting invasion and metastasis by some signal pathways, including RhoA/ROCK/MMPs axis, miR-1294/PLK1 axis, miR-498/XBP1 axis, miR-148A-3p/mcl-1/Wnt/β-catenin axis, miR-145-5p/TRPC6 axis, miR-26a-5p/MMP-14/p38MAPK/HSP27 aix, or Twist1/EMT axis, and some molecule, including miR-145-5p, EMT, EZH2, or miR-382 in cancers. The gene discussed is TUG1; the disease is cancer.