lncRNA TUG1 also regulates invasion and metastasis through other mechanisms, such as via miR-145-5p/TRPC6 (Xiaoqiang et al. 2021), the miR-26a-5p/matrix metalloproteinases-14 (MMP-14)/p38 mitogen-activated protein kinase (p38MAPK)/HSP27 (heat shock protein 27) axis (Lei et al. 2019) the TUG1/Twist1/EMT signalling pathway ,(Shen et al. 2020), or by affecting the EMT (Liang et al. 2016) to promote proliferation and metastasis in colorectal cancer cells. The gene discussed is TWIST1; the disease is colorectal cancer.