lncRNA TUG1 affected proliferation by regulating wnt/β-catenin signal pathway, miR-384, miR-498, miR-29c, miR-299-3p, or microRNA-9, in oral squamous cell carcinoma, nasopharyngeal carcinoma,esophageal squamous cell carcinoma, pancreatic cancer, breast cancer, respectively. This evidence concerns the gene TUG1 and esophageal squamous cell carcinoma.