lncRNA TUG1 also regulates invasion and metastasis through other mechanisms, such as via miR-145-5p/TRPC6 (Xiaoqiang et al. 2021), the miR-26a-5p/matrix metalloproteinases-14 (MMP-14)/p38 mitogen-activated protein kinase (p38MAPK)/HSP27 (heat shock protein 27) axis (Lei et al. 2019) the TUG1/Twist1/EMT signalling pathway ,(Shen et al. 2020), or by affecting the EMT (Liang et al. 2016) to promote proliferation and metastasis in colorectal cancer cells. This evidence concerns the gene TUG1 and colorectal cancer.