Altogether, our results suggest the occurrence of an intricate CXCL2/CXCL8-CXCR2 axis in the modulation of cisplatin sensitivity by OC cells, thus corroborating with an important role of TME and a potential autocrine effect of CXCL2/CXCL8 on CXCR2 expressed by tumor cells. The gene discussed is CXCR2; the disease is neoplasm.