CD274 and neoplasm: Constitutive expression of PD-L1 by tumor cells is frequently due to active oncoproteins, such as MYC, EML4-ALK, and AKT (Ota et al., 2015; Parsa et al., 2007), but how oncogenic forms of the epidermal growth factor receptor (EGFR) regulate the expression of PD-L1 is still incompletely understood.