CXCL8 and Abnormal renal physiology: Nine proinflammatory cytokines compatible with M1 polarization (IL-8, FGF, sIL-2R, GM-CSF, TNFα, MIP1α, G-CSF, IFNγ, and MIP1β) correlated with renal dysfunction (i.e. peak of serum creatinine), but also with the ratio urine albumin/creatinine to protein/creatinine (ACR/PCR), reflecting glomerular involvement (Fig 4B).