MTOR and epilepsy: To further confirm the necessity of increased mTOR activity in a subset of cells, irrespective of the presence of a cortical malformation, for the development of epilepsy, we used IUE to focally introduce in the SScx a Lox-Stop-Lox (LSL)-RHEBp.P37L vector or floxed-RHEBp.P37L vector together with a vector expressing the ERT2CreERT2 fusion protein (Fig 4).