Using IUE, we have previously shown that overexpression of the RHEBp.P37L mutant, but not RHEB WT, results in the formation of a heterotopic nodule as well as spontaneous epilepsy in 100% of the targeted mice [23], providing us with a valuable model to study the mechanisms behind mTORC1-dependent and MCD-related epilepsy. The gene discussed is RHEB; the disease is epilepsy.