Multiparametric magnetic resonance imaging (mp-MRI) has shown high negative predictive value for the detection of clinically significant PCa (defined as Gleason score ≥ 3 + 4)3, and it is currently recommended for all patients with elevated PSA and clinical suspicion of PCa prior to biopsy (EAU guidelines: https://uroweb.org/guideline/prostate-cancer/). This evidence concerns the gene KLK3 and Familial prostate cancer.