Compared with the control group, the protein level of p-JNK was 0.89-fold higher in the 5-μM Tan I-treated CML cells, while when the concentration of Tan I was increased to 10 μM, the protein level of p-JNK reached 2.09-fold higher levels than that of the control group (Figure 3B). The gene discussed is MAPK8; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.