The activation of canonical Wnt signaling in EpCAMlo colon cancer cells is of interest in view of the fact that both cell lines harbor mutations (loss and gain of APC and β-catenin function in SW480 [Nishisho et al., 1991] and HCT116 [Ilyas et al., 1997], respectively) predicted to result in the constitutive activation of the pathway. The gene discussed is APC; the disease is colonic neoplasm.