SPARC and colonic neoplasm: Partial EMT cells, predicted by RNAvelocity to transit between states, are characterized not only by the co-expression of E- and M-specific genes at intermediate levels, but also by increased expression of specific genes like SPARC (Secreted Protein Acidic and Rich in Cysteine, also known as osteonectin), encoding for a matricellular protein involved in the modulation of cell–cell and cell–matrix interactions and known as a prognostic marker in colon cancer (Kim et al., 2013).