Overall, we speculate that the modest reduction in Col1a1 expression and altered expression of Scx, as well as other ECM proteins such as Tnc, Lum, and Tnmd, could be associated with the observed aberrations in collagen fibrillogenesis seen in Crtap-/- mice, and may indicate an increased remodeling or repair response similar to that seen in OI bone (Grafe et al., 2014). Here, TNC is linked to osteogenesis imperfecta.