Interestingly, although there is no known data on the phenotypic effect of mutating the equivalent residue in human Orc4 (Arg205), mutation of the analogous residue in Orc1 (Arg666, to Trp) has been linked to Meier-Gorlin syndrome (Guernsey et al., 2011). Here, ORC4 is linked to Meier-Gorlin syndrome.