Encouragingly, tumour margin penetration within a biologically active drug concentration range has been recently reported for the PARP1 inhibitor olaparib (Lynparza) in combination with temozolomide chemotherapy as part of the OPARATIC trial [145], and it will be interesting to see the results from other DDR inhibitor trials for glioblastoma when they are reported (Table 1). The gene discussed is PARP1; the disease is neoplasm.