MAPT and Alzheimer disease: For example, Slaets et al. found a significant, moderately positive correlation between Tau and αSyn and between pTau181 and αSyn in AD patients but not in DLB patients (Slaets et al. 2014) Interestingly, not only association of αSyn with biomarkers of neurodegeneration (Tau) but also with biomarkers more specific for AD (Aβ peptides) was postulated; Buddhala et al. observed a positive correlation between CSF αSyn and Aβ1-42 in PD patients, but not in controls, confirming a pathophysiologic connection between the metabolisms of these proteins in PD (Buddhala et al. 2015).