It has been suggested that the mechanism of P407-induced hypertriglyceridemia involves elevated TG levels resulting from the inhibition of LPL [20], and P407-induced hypercholesterolemia involves the indirect stimulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and decreased LDL receptor expression in the liver [26,27]. The gene discussed is HMGCR; the disease is familial hypercholesterolemia.