According to literature, male sex reversal syndrome's patients without sexual ambiguity (5/12 in our case) are SRY+ and have characters similar to Klinefelter syndrome, and those with sexual ambiguity (7/12 in our case) are SRY- and have hypospadias or insufficient degrees of virilization in the external genitalia. The gene discussed is SRY; the disease is hypospadias.