An in vitro cell culture assay also showed a greater proliferative activity in human endometrial epithelial cells with concurrent ARID1A and PTEN inactivation than cells with either PTEN or ARID1A inactivated, suggesting the potential of ARID1A as a gatekeeper in the preneoplastic endometrial epithelium to carcinoma transition [18]. Here, PTEN is linked to carcinoma.