TP53 and carcinosarcoma: However, cooccurrence of mutations in TP53 and PTEN genes in tumors from carcinosarcoma, otherwise those two genes were mutually exclusive and showed a tendency to be found exclusively in one of two (endometrioid or serous) histologic subtypes in previous studies, suggested that carcinosarcoma originated from a common origin for carcinomatous and sarcomatous components [7, 39–41].