In head and neck cancer, MPC1 regulates ferroptosis in vivo and in vitro (You, Lee & Roh, 2021); meanwhile, recent studies have confirmed the significant role of ferroptosis in CRC (Xu et al., 2021); so, it may be promising to further study whether MPC1 can modulate ferroptosis in CRC. The gene discussed is MPC1; the disease is colorectal carcinoma.