MAPT and Alzheimer disease: In AD, markers for oxidative stress and mitochondrial dysfunction have been reported in close proximity to key pathological hallmarks of AD, including extracellular amyloid-beta (Aβ) deposits, and intracellular neurofibrillary tangles containing hyperphosphorylated tau protein (Birnbaum et al. 2018; Butterfield and Boyd-Kimball 2018; Cheignon et al. 2018; Martins et al. 2018).