For instance, EV‐derived angiopoietin‐2 from hepatocellular carcinoma was delivered into recipient HUVECs via endocytosis and it can be recycled to induce angiogenesis by activating the Akt/eNOS and Akt/β‐catenin axes (Xie et al., 2020). This evidence concerns the gene AKT1 and hepatocellular carcinoma.