Soluble E‐cadherin was reportedly localized on the surface of EVs from ovarian cancer cells and it can bind to and heterodimerize with VE‐cadherin on endothelial cells, which activated the β‐catenin and NF‐κB pathways to promote angiogenesis (Tang et al., 2018). This evidence concerns the gene CDH1 and ovarian carcinoma.