Tian et al. have reported that calycosin was able to inhibit both ER− and ER+ breast cancer cell proliferation in a dose-dependent manner and the inhibitory effects were associated with noncoding RNA WDR7-7 expression level by inducing G-protein coupled estrogen receptor 30 (GPR30) and RASD1 via Erk1/2 and Akt transduction pathway [14, 15]. The gene discussed is ESR1; the disease is breast cancer.