With network analysis, the associated relationships between the target gene and IS-related disease were predicted; i.e., GRIN1 is associated with AD and epilepsy, PTGES is related to AD and ALS, ADRA1A has a link with depression, CDK5 connects with AD, depression, and ALS, while SULT1E1 may have an association with ALS. This evidence concerns the gene PTGES and depressive symptom measurement.