CRH and Anxiety: In this study, the anxiolytic effects of Sau during EtOHW were further corroborated by the finding that Sau treatment blocked EtOHW-induced increases in the plasma CORT concentration and CRF protein level in the BNST; oversecretion of CORT and CRF in blood and the BNST, respectively, are the hormonal and neurochemical hallmarks of anxiety in rats [12, 44].