As shown in Figure 4, plasma CORT levels were significantly increased in EtOH-treated control rats relative to saline-treated controls (F5, 36 = 24.00, p < 0.001; saline/vehicle (n = 7) versus EtOH/vehicle (n = 7), p < 0.001), indicating a state of anxiety in rats during EtOHW. This evidence concerns the gene CORT and Anxiety.