The Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy working committee suggested that histologic grade II and III IDH-wild-type astrocytic glioma should be referred as diffuse astrocytic glioma, IDH-wild-type, for these gliomas containing high-level EGFR amplification or TERT promoter mutations [21]. The gene discussed is EGFR; the disease is central nervous system cancer.