High levels of IL-6 and TNF-α, important mediators in the switch from acute to chronic inflammation, are present in periodontal gingival crevicular fluid and gingival tissues, and after nonsurgical periodontal therapy, reduced levels of TNF-α, IL-1β, and IL-6 were observed, confirming their role in periodontal disease [24, 25]. Here, TNF is linked to periodontal disorder.