The coordination of GluA2-AMPAR subunit expression and targeting during neuronal development participates in synaptic network establishment through precise dendritic spine morphological reorganisation of excitatory neurons [41, 42], and alterations in AMPAR composition are generally observed in young animals; these alterations are associated with immature synapses and cognitive impairment [16, 43]. Here, GRIA2 is linked to Cognitive impairment.