In line with our data, several studies reported that CYGB is upregulated under strong hypoxic conditions in Hep3B, renal clear cell carcinoma (RCC4), transformed human bronchial epithelial cells (BEAS-2B), human cervix carcinoma (HeLa) and murine derived hippocampal neurons (HN33) cells28,42,43. This evidence concerns the gene CYGB and clear cell renal carcinoma.