When clinical symptoms in COVID-19 patients were compared with EBV VCA IgM antibody, EBV/SARS-CoV-2 coinfection patients had a higher risk to report fever symptom than SARS-CoV-2 infection alone patients (OR, 3.09; 95% CI 1.11–8.56; P = 0.03). The gene discussed is CD40LG; the disease is COVID-19.