Since dopamine supersensitivity is associated with upregulation of D2 receptors, D2R antagonists with high affinities for the D2 receptor may be more effective than antipsychotics with lower affinities to treat the related psychosis, with the exception of clozapine that has a lower affinity but has the potential to reverse dopamine supersensitivity43. This evidence concerns the gene DRD2 and psychotic disorder.