Finally, the density of PD-L1+ tumor cells significantly decreased post-therapy [median percent of positive cells (range): 0.4 (0.02–1.13) versus 0.05 (0.02–0.84), p = 0.0079] (Fig. 3h), whereas the density of PD-L1+ immune cells was not significantly altered (data not shown). Here, CD274 is linked to neoplasm.