Figure 2a highlights this for SVA_67, located upstream of the KANSL1 gene, showing PD subjects with AA genotype of SVA_67 had a significantly higher mean caudate/putamen CDR (3.81, 95% CI 3.12–4.51) than those with both PA (2.63, 95% CI 2.43–2.83, p = 0.004) and PP (2.64, 95% CI 2.49–2.79, p = 0.004) genotypes at 12 months. This evidence concerns the gene KANSL1 and Parkinson disease.