GBA1 and Parkinson disease: We generated a new strain of gba mutant zebrafish using TALEN-mediated genome editing to further analyze the relationship between the cytosolic dsDNA of mitochondrial origin and cell death in PD, and the homozygous mutants showed a decrease in the levels and activity of the gba protein in the brain (Fig. 4a and Supplementary Fig. 4a, b).