CASP3 and neuroblastoma: In SH-SY5Y neuroblastoma cells, the depletion of PINK1, ATP13A2, and/or GBA resulted in cell death, as demonstrated by elevated LDH levels, decreased cell viability, and increased levels of the cleaved form of caspase-3 or Gasdermin D (Fig. 1a and Supplementary Fig. 1a, b).