TGFB2 and obesity due to melanocortin 4 receptor deficiency: In contrast the pro-inflammatory bacteria Enterococcus correlates positively with fecal neopterin and ferritin and negatively with the butyrate producing bacteria Roseburia. Finally, Akkermansia that has been inversely associated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation21, but also in response to cancer immunotherapy22, positively correlate with butyrate producing bacteria and TGFb2 and negatively correlate with inflammatory parameters (fecal neopterin, CD14+ monocytes and neutrophils).