To study the contribution of microglial phagocytosis to the loss of Aß plaques-associated blood vessels, we generated a new AD mouse model where tdTomato was conditionally expressed in the cytoplasm of endothelial cells (APP-PSEN1/+; Cdh5-Cre::ERT2/+; tdTomato/+) upon tamoxifen (TMX) treatment. This evidence concerns the gene MAPK3 and Alzheimer disease.