PKM and hepatocellular carcinoma: Moreover, HCA/HCC-related biomarkers (i.e., PKM2, β-catenin, and p62)54 (Fig. 6c); and genes associated with cellular proliferation and HCA/HCC development (i.e., Tgfb1, Glul, and Ctnnb1)54 were also partially reversed with hG6PC S298C mRNA treatment (Supplementary Fig. 4a).