Our independent analysis of primary ER+PIK3CA-mutant breast cancers, which exhibit high INPP4B expression, identified these and additional upregulated Wnt genes (LEF1, MYCN, FZD7, SFRP2, TCF7L1, CTNNB1, FZD4, and SFRP1). The gene discussed is FZD4; the disease is breast cancer.