INPP4B and breast cancer: Here, INPP4B protein expression was examined by immunohistochemistry using a validated monoclonal INPP4B (3D5) antibody6 on two independent tissue cohorts; one tissue microarray containing 224 primary human breast cancers with 32 tumor-adjacent normal breast tissues (US Biomax) (Supplementary Fig. 1a), and a second cohort of 107 primary breast cancers collected as part of the Melbourne Collaborative Cohort Study (MCCS)6.