Although Hrs knockdown did not affect the size or weight of GFP-vector tumors, the enhanced growth of GFP-INPP4B tumors was suppressed by Hrs depletion (Fig. 5e–g), indicating that INPP4B promotes the proliferation and tumor growth of PIK3CA-mutant ER+ breast cancer cells in an Hrs-dependent manner. The gene discussed is PIK3CA; the disease is breast carcinoma.