However, the CXCR5+CD8+T signature score is relatively high in the MSI, EBV, and GS subtypes but is the lowest in the CIN subtype (P < 0.001, P < 0.0001, and P < 0.0001, respectively; Fig. 4a). The gene discussed is CXCR5; the disease is cervical squamous intraepithelial neoplasia.