APOE and Alzheimer disease: Beyond the APOE locus, KnockoffScreen identified several other loci that potentially affect AD risk, including KAT8 and an intergenic region on chromosome 18q22 between DSEL and TMX3. KAT8 (lysine acetyltransferase 8) has been recently identified in two large scale GWAS focused on clinically diagnosed AD and AD-by-proxy individuals35,36.