AKT1 and cancer: To further investigate the downstream signaling pathways of CBX7–AKR1B10 axis, western blotting was used to detect the protein levels of active β-catenin, p-AKT, p-STAT3, and p-ERK, the key molecules in the classic signaling pathways, which have been reported to participate in diverse cellular processes such as proliferation, survival, and differentiation in cancer cells.